The following code allows us to monkey patch the json() method that is returned by requests.post().

import requests
from mock import MagicMock


@mock.patch.object(requests, 'post')
def my_function(self, post):
    attrs = {'json.return_value': {'id': 1}}
    post.return_value = MagicMock(**attrs)

    r = requests.post()
    r.json()['id']

Source: https://docs.python.org/dev/library/unittest.mock.htmll#unittest.mock.NonCallableMock