#!/usr/bin/env python

import os

os.environ['DJANGO_SETTINGS_MODULE'] = 'mysite.settings'

import django
django.setup()

from app.models import Class

# Your scripting here.

Sources:
https://docs.djangoproject.com/en/1.10/intro/tutorial02/#playing-with-the-api
https://docs.djangoproject.com/en/1.10/topics/settings/#on-the-server-mod-wsgi